Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8.3
Supplement Facts
Serving Size: 1 Vegetarian capsule
Amount Per Serving
%DV
Bio-Quercetin® Proprietary Blend providing 35% quercetin (10 mg) [from Japanese sophora concentrate flower bud)], 30% galactomannans (8 mg) [from fenugreek (seed)]
30 mg
**
Top Medical Research Studies
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
8
We investigated how quercetin can help protect kidneys from damage caused by diabetes in rats. Our study involved forty male Wistar rats divided into different groups to compare the effects of quercetin treatment before and after diabetes was induced.
We found that quercetin significantly reduced kidney dysfunction symptoms and oxidative stress markers compared to untreated diabetic rats. This improvement linked to quercetin's ability to enhance antioxidant defenses and disrupt harmful signaling pathways. However, we observed that pretreatment with quercetin was more effective than post-treatment, suggesting timing matters in its effectiveness.
We found that quercetin significantly reduced kidney dysfunction symptoms and oxidative stress markers compared to untreated diabetic rats. This improvement linked to quercetin's ability to enhance antioxidant defenses and disrupt harmful signaling pathways. However, we observed that pretreatment with quercetin was more effective than post-treatment, suggesting timing matters in its effectiveness.
Read More
Most Useful Reviews
9
Effective for allergies
7 people found this helpful
I adore this product! Suffering from MCAS (mast cell activation disorder) and histamine intolerance, I previously relied on the expensive Cromolyn. Quercetin is even more effective in blocking mast cell cytokine release and alleviating contact dermatitis. I've tried others but Life Extension Bio-Quercetin is unparalleled due to its absorption. I take one capsule daily before meals. It really works, as I notice significantly fewer allergy symptoms now.
Read More
9
Antioxidant properties
2 people found this helpful
I ordered this quercetin for recovery post-COVID. It’s included in the medical protocol for treatment after illness. The packaging is compact, and the capsules are tiny and easy to swallow. As a powerful antioxidant, I have faith in its efficacy, especially for those recovering from COVID. Highly recommended!
Read More
9
Clear improvement
2 people found this helpful
Excellent! This is a great product. I am ordering a second course already. After COVID, I had memory and concentration issues. After a week of taking it, I felt a marked improvement. I didn’t take anything else, so it was definitely Quercetin that helped. I've decided to repeat it three months later.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
Read More
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Read More
9
We explored how Sendeng-4, a traditional Mongolian medicine, can ease rheumatoid arthritis (RA). By using advanced methods to analyze its active components, we identified key phytochemicals and mapped their effects on biological pathways.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
Read More
9
Quercetin liposomes aid diabetes therapy
We observed that a new form of quercetin, delivered in lipid nanoparticles, can help alleviate diabetes symptoms in rats. This improved bioavailable quercetin significantly reduced blood glucose levels and lowered pancreatic oxidative stress and inflammation.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
Read More
8
Quercetin shows promise for RA treatment
We examined the active components in the Additive Sishen Decoction (ASSD), a traditional Chinese medicine for rheumatoid arthritis (RA). Our findings revealed that key ingredients—quercetin, kaempferol, and luteolin—play a significant role in reducing inflammation through specific pathways.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective for allergies
7 people found this helpful
I adore this product! Suffering from MCAS (mast cell activation disorder) and histamine intolerance, I previously relied on the expensive Cromolyn. Quercetin is even more effective in blocking mast cell cytokine release and alleviating contact dermatitis. I've tried others but Life Extension Bio-Quercetin is unparalleled due to its absorption. I take one capsule daily before meals. It really works, as I notice significantly fewer allergy symptoms now.
Read More
9
Antioxidant properties
2 people found this helpful
I ordered this quercetin for recovery post-COVID. It’s included in the medical protocol for treatment after illness. The packaging is compact, and the capsules are tiny and easy to swallow. As a powerful antioxidant, I have faith in its efficacy, especially for those recovering from COVID. Highly recommended!
Read More
9
Clear improvement
2 people found this helpful
Excellent! This is a great product. I am ordering a second course already. After COVID, I had memory and concentration issues. After a week of taking it, I felt a marked improvement. I didn’t take anything else, so it was definitely Quercetin that helped. I've decided to repeat it three months later.
Read More
9
Relieves throat pain
1 people found this helpful
After COVID-19, I had persistent pain in my throat, but while taking quercetin, it vanished. I've ordered two jars for a complete course. The bioform is superior in absorption compared to regular quercetin and I find it truly effective.
Read More
9
Effective for gut
A very good antioxidant product, effective for leaky intestinal disorders, and it also calms rhinitis and allergic coughs.
Read More
Frequently Asked Questions
9
Clear improvement
2 people found this helpful
Excellent! This is a great product. I am ordering a second course already. After COVID, I had memory and concentration issues. After a week of taking it, I felt a marked improvement. I didn’t take anything else, so it was definitely Quercetin that helped. I've decided to repeat it three months later.
9
Relieves throat pain
1 people found this helpful
After COVID-19, I had persistent pain in my throat, but while taking quercetin, it vanished. I've ordered two jars for a complete course. The bioform is superior in absorption compared to regular quercetin and I find it truly effective.
7.5
Reduces allergy onset
4 people found this helpful
This drug was taken to alleviate ragweed allergy symptoms. Miraculously, my symptoms didn't begin until around the 25th of August, rather than the usual onset in early August. Consequently, my reliance on hormonal allergy sprays decreased by three weeks. I plan to order this again next season and highly recommend its efficacy.
9
Effective for allergies
7 people found this helpful
I adore this product! Suffering from MCAS (mast cell activation disorder) and histamine intolerance, I previously relied on the expensive Cromolyn. Quercetin is even more effective in blocking mast cell cytokine release and alleviating contact dermatitis. I've tried others but Life Extension Bio-Quercetin is unparalleled due to its absorption. I take one capsule daily before meals. It really works, as I notice significantly fewer allergy symptoms now.
7.5
Recovery aid
1 people found this helpful
I ordered this after coronavirus along with Quercetin; I highly recommend it to aid recovery and avoid side effects post-COVID, particularly if there were vessel issues during the illness.
8
Quercetin shows promise for RA treatment
We examined the active components in the Additive Sishen Decoction (ASSD), a traditional Chinese medicine for rheumatoid arthritis (RA). Our findings revealed that key ingredients—quercetin, kaempferol, and luteolin—play a significant role in reducing inflammation through specific pathways.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
These ingredients inhibit proinflammatory factors by affecting glucose metabolism in macrophages. We employed protein interaction networks and molecular simulations to clarify their mechanisms, showing that quercetin contributes significantly to ASSD’s therapeutic effects.
Overall, we established that quercetin can be a valuable aid in managing RA symptoms.
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
8
Quercetin combined with chondroitin sulfate
We examined how quercetin interacts with chondroitin sulfate to potentially alleviate rheumatoid arthritis, a challenging autoimmune disorder linked to bacterial aggressors like Proteus mirabilis. This study utilized both in vitro and in vivo methods to identify their combined effects.
The results indicated that these compounds could reduce inflammation and oxidative stress while showing promising antibacterial properties. Zebrafish treated with the combination exhibited better survival rates under bacterial stress and showed significant metabolic improvements. Overall, it appears that quercetin and chondroitin sulfate might be valuable in managing this condition, but further research is needed to fully understand their benefits.
The results indicated that these compounds could reduce inflammation and oxidative stress while showing promising antibacterial properties. Zebrafish treated with the combination exhibited better survival rates under bacterial stress and showed significant metabolic improvements. Overall, it appears that quercetin and chondroitin sulfate might be valuable in managing this condition, but further research is needed to fully understand their benefits.
8
We examined the effectiveness of a topical gel combining Teriflunomide and Quercetin for treating rheumatoid arthritis. Through a carefully designed experiment, we created transferosomes that showed impressive localized delivery to joint tissues and sustained drug release.
Our findings indicate that this combination therapy significantly reduced inflammatory markers and demonstrated notable anti-arthritic effects in rat models. Importantly, the gel was shown to be non-toxic, indicating a safe alternative to traditional oral treatments.
Overall, this innovative approach may minimize systemic side effects while still effectively managing rheumatoid arthritis symptoms.
Our findings indicate that this combination therapy significantly reduced inflammatory markers and demonstrated notable anti-arthritic effects in rat models. Importantly, the gel was shown to be non-toxic, indicating a safe alternative to traditional oral treatments.
Overall, this innovative approach may minimize systemic side effects while still effectively managing rheumatoid arthritis symptoms.
8
We investigated how JPZS granules may help manage systemic lupus erythematosus (SLE) by regulating podocyte autophagy. Using a clinical trial involving 46 patients, we divided them into two groups: one receiving standard treatment and the other adding JPZS granules.
We found that the active ingredients, including quercetin, effectively reduced certain harmful protein levels and improved markers of podocyte health after 12 weeks. Overall, JPZS granules appear to work by targeting the JAK/STAT pathway, potentially offering a new avenue to alleviate SLE symptoms.
We found that the active ingredients, including quercetin, effectively reduced certain harmful protein levels and improved markers of podocyte health after 12 weeks. Overall, JPZS granules appear to work by targeting the JAK/STAT pathway, potentially offering a new avenue to alleviate SLE symptoms.
References
- Ren J, Liu Z, Qi X, Meng X, Guo L, et al. Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification. Drug Des Devel Ther. 2025;19:405. doi:10.2147/DDDT.S489323
- Yang J, Yang H, Wang F, Dai Y, Deng Y, et al. Bioinformatics identification based on causal association inference using multi-omics reveals the underlying mechanism of Gui-Zhi-Shao-Yao-Zhi-Mu decoction in modulating rheumatoid arthritis. Phytomedicine. 2025;136:156332. doi:10.1016/j.phymed.2024.156332
- Zhendong Y, Changjun C, Haocheng H, Qibin L, Dailing C, et al. Regulation of macrophage polarization and pyroptosis by 4-methylcatechol alleviates collagen-induced arthritis via Nrf2/HO-1 and NF-κB/NLRP3 signaling pathways. Int Immunopharmacol. 2025;146:113855. doi:10.1016/j.intimp.2024.113855
- Priya PS, Murugan R, Srileka R, Ramya Ranjan Nayak SP, Margesan T, et al. Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms. Microb Pathog. 2024;197:107086. doi:10.1016/j.micpath.2024.107086
- Xiong F, Shen K, Long D, Zhou S, Ruan P, et al. Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway. Immun Ageing. 2024;21:69. doi:10.1186/s12979-024-00474-9
- Karnam S, Jindal AB, Paul AT. Quality by design-based optimization of teriflunomide and quercetin combinational topical transferosomes for the treatment of rheumatoid arthritis. Int J Pharm. 2024;666:124829. doi:10.1016/j.ijpharm.2024.124829
- Zhang F, Zhang Y, Zhou J, Cai Y, Li Z, et al. Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling. Mol Med. 2024;30:170. doi:10.1186/s10020-024-00929-1
- Wu Z, Hu J, Li Y, Yao X, Ouyang S, et al. Assessment of renal pathophysiological processes and protective effect of quercetin on contrast-induced acute kidney injury in type 1 diabetic mice using diffusion tensor imaging. Redox Rep. 2024;29:2398380. doi:10.1080/13510002.2024.2398380
- Guo X, Wu W, Ran Q, Wang L, Li Y, et al. Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology. J Ethnopharmacol. 2024;334:118524. doi:10.1016/j.jep.2024.118524
- Pei C, Yu J, Wang G, Jia YR, Shi X, et al. Exploring the mechanism of Sendeng-4 against rheumacid arthritis through integrated serum pharmacochemistry, transcriptomics, and network pharmacology. Biomed Chromatogr. 2024;38:e5893. doi:10.1002/bmc.5893
- Zhou F, Guo YX, Gao R, Ji XY, Tang YX, et al. Quercetin regulates dendritic cell activation by targeting STAT4 in the treatment of experimental autoimmune encephalomyelitis. Toxicol Appl Pharmacol. 2024;488:116980. doi:10.1016/j.taap.2024.116980
- Hossein A, Firouzeh G, Zeinab K, Gholamreza D. Quercetin prevents kidney against diabetes mellitus (type 1) in rats by inhibiting TGF-β/apelin gene expression. Mol Biol Rep. 2024;51:677. doi:10.1007/s11033-024-09617-z
- Hou Y, Chen C, Li Z, Wu J, Lyu S, et al. Protective effect of quercetin against macrophage-mediated hepatocyte injury via anti-inflammation, anti-apoptosis and inhibition of ferroptosis. Autoimmunity. 2024;57:2350202. doi:10.1080/08916934.2024.2350202
- Li X, Wang X, Qu X, Shi N, Li Q, et al. Microenvironmental Enzyme-Responsive Methotrexate Modified Quercetin Micelles for the Treatment of Rheumatoid Arthritis. Int J Nanomedicine. 2024;19:3259. doi:10.2147/IJN.S457004
- Chen J, Huang C, Li M. [ granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:465. doi:10.12122/j.issn.1673-4254.2024.03.07
- Khater SI, El-Emam MMA, Abdellatif H, Mostafa M, Khamis T, et al. Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA. Life Sci. 2024;344:122546. doi:10.1016/j.lfs.2024.122546
